Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase
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Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase.
The capacity of platelets treated with nonlytic concentrations of the C5b-9 proteins to catalyze prothrombin activation and thereby trigger clot formation has been investigated. When suspended in the presence of exogenous factors Xa and Va, gel-filtered platelets treated with purified C5b-9 proteins catalyzed prothrombin to thrombin conversion at rates up to tenfold above controls, and exceeded...
متن کاملComplement Proteins C 5 b - 9 Stimulate Procoagulant Activity Through Platelet
The capacity of platelets treated with nonlytic concentrations of the C5b-9 proteins to catalyze prothrombin activation and thereby trigger clot formation has been investigated. When suspended in the presence of exogenous factors Xa and Va. gel-filtered platelets treated with punfled C5b-9 proteins catalyzed pnothrombin to thrombin conversion at rates up to tenfold above controls, and exceeded ...
متن کاملThe secretory release reaction initiated by complement proteins C5b-9 occurs without platelet aggregation through glycoprotein IIb-IIIa.
The secretory and aggregation responses of stirred platelets exposed to complement proteins C5b-9 was investigated. C5b-9 assembly on the platelet surface resulted in the release of dense granule adenosine triphosphate (ATP) accompanied by a decrease in sample turbidity, but no detectable cell lysis. Inhibition of cellular protein kinase C completely blocked the C5b-9 initiated release of ATP, ...
متن کاملThe Secretory Release Reaction Initiated by Complement Proteins C5b-9 Occurs Without Platelet Aggregation Through Glycoprotein tib-Illa
The secretory and aggregation responses of stirred platelets exposed to complement proteins C5b-9 was investigated. C5b-9 assembly on the platelet surface resulted in the release of dense granule adenosine triphosphate (ATP) accompanied by a decrease in sample turbidity. but no detectable cell lysis. Inhibition of cellular protein kinase C completely blocked the C5b-9 initiated release of ATP. ...
متن کاملComplement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired stem-cell disorder in which the glycolipid-anchored membrane proteins, including the cell-surface complement inhibitors, CD55 and CD59, are partially or completely deleted from the plasma membranes of mature blood cells. To gain insight into the pathogenesis of thrombosis that is frequently observed in this disorder, the procoagulant resp...
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ژورنال
عنوان ژورنال: Blood
سال: 1986
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v68.4.875.875